Loaʻa nā ʻike hou o Metformin

1. Kuhi ʻia e hoʻomaikaʻi i ka hopena o ka maikaʻi ʻole o ka puʻupaʻa a me ka make ʻana mai nā maʻi puʻupaʻa
Ua hoʻokuʻu ʻia kahi nūhou a WuXi AppTec e ka Medical New Vision e hōʻike ana i kahi noiʻi o 10,000 poʻe e hoʻomaikaʻi paha ka metformin i ka makaʻu ʻole o ka puʻuwai a me ka make ʻana mai nā maʻi puʻupaʻa.

Ua hōʻike ʻia kahi noiʻi i paʻi ʻia ma ka puke pai ʻo ʻAmelika Diabetes Association (ADA) ʻo “Diabetes Care” (Diabetes Care) ua hōʻike ʻia ka lāʻau a me ke anamanaʻo ola ʻana ma mua o 10,000 mau kānaka i hōʻike ʻia e pili pū kekahi ʻano maʻi diabetes he 2 me ka maʻi maʻi maʻi maʻi maʻi (CKD) i Metformin. kahi hoʻemi i ka makaʻu o ka make a me ka maʻi hōʻino hope loa (ESRD), a ʻaʻole hoʻonui i ka makaʻu o ka lactic acidosis.

ʻO ka maʻi maʻi kōpaʻa kahi maʻi maʻamau o ka maʻi kō. Ke noʻonoʻo nei i nā mea maʻi me nā maʻi puʻupaʻa liʻiliʻi e kuhikuhi ʻia i metformin, ua noiʻi ka hui noiʻi i nā maʻi he 2704 i kēlā me kēia hui ʻelua e lawe ana i ka metformin a lawe ʻole i ka metformin.

Ua hōʻike ʻia nā hopena i hoʻohālikelike ʻia me ka poʻe i lawe ʻole i ka metformin, ʻo nā mea maʻi i lawe i ka metformin he 35% ka hoʻoliʻiliʻi o ka make o nā kumu āpau a he 33% ka hoʻoliʻiliʻi o ka makaʻu o ka holomua i ka hopena o ka maʻi hōʻino hope loa. Ua kū mālie kēia mau pōmaikaʻi ma hope o 2.5 mau makahiki o ka lawe ʻana i ka metformin.

Wahi a ka hōʻike, i nā makahiki i hala aku nei, paipai nā kulekele o ka US FDA e hoʻomaha i ka hoʻohana ʻana o metformin i nā mea maʻi me ka maʻi diabetes type 2 me nā maʻi puʻuwai maʻi mau, akā i nā mea maʻi me ka maʻi puʻuwai liʻiliʻi wale nō. No nā mea maʻi me ke akahai (pae 3B) a me nā maʻi puʻuwai mau loa, hoʻopaʻapaʻa ka hoʻohana ʻana o metformin.

ʻO Kauka Katherine R. Tuttle, he polofesa ma ke Kulanui o Wakinekona i ʻAmelika Hui Pū ʻIa, ua ʻōlelo ʻo ia: “He mea hōʻoluʻolu nā hopena o ke aʻo ʻana. ʻOiai i nā mea maʻi me ka maʻi puʻuwai koʻikoʻi, haʻahaʻa loa ka makaʻu o ka lactic acidosis. No nā mea maʻi me ka maʻi diabetes ʻelua a me nā maʻi puʻuwai maʻi mau, ʻo metformin paha kahi mea pale i ka make a me kahi lāʻau nui no ka holo pono ʻole o ka puʻupaʻa, akā ʻoiai he loiloi hou kēia a me ka nānā ʻana, pono e wehewehe pono ʻia nā hopena.

2. Nā hiki lapaʻau like ʻole o ka metformin lāʻau lapaʻau
Hiki ke ʻōlelo ʻia ʻo Metformin he lāʻau kahiko kahiko ia no ka manawa lōʻihi. I ka piʻi ʻana o ka noiʻi lāʻau hypoglycemic, i ka 1957, ua paʻi ka ʻepekema Palani ʻo Stern i kāna mau hopena noiʻi a ua hoʻohui i ka hua lilac i loaʻa ka hana hypoglycemic i nā pī kao. ʻO Alkali, kapa ʻia metformin, Glucophage, ʻo ia hoʻi ka mea e ʻai i ke kō.

I ka makahiki 1994, ua ʻae ʻia ka metformin e ka US FDA no ka hoʻohana ʻana i ka maʻi diabetes 2. ʻO Metformin, ma ke ʻano he lāʻau lapaʻau no ka mālama ʻana i ka maʻi diabetes ʻano 2, i helu ʻia ma ke ʻano he lāʻau hypoglycemic laina mua i nā ʻano lula lapaʻau ma ka home a me nā ʻāina ʻē. Loaʻa iā ia nā pōmaikaʻi o ka hopena hypoglycemic pololei, haʻahaʻa o ka hypoglycemia, a me ke kumu kūʻai haʻahaʻa. ʻO kēia ka lāʻau lapaʻau hoʻohana nui loa ʻO kekahi o ka papa o nā lāʻau hypoglycemic.

Ma ke ʻano he lāʻau i hoʻāʻo ʻia i ka manawa, kuhi ʻia aia ma kahi o 120 miliona mau hoʻohana o ka metformin ma ka honua holoʻokoʻa.

Me ka hohonu o ka noiʻi, ua hoʻonui mau ʻia ka mana pono o ka metformin. Ma waho aʻe o nā ʻike hou loa, ua ʻike ʻia ka metformin e aneane 20 mau hopena.

1. Ka hopena kūnewa
I kēia manawa, ua ʻae ka US Food and Drug Administration i ka hoʻokolohua hoʻokolohua o "ka hoʻohana ʻana i ka metformin e kaua i ka ʻelemakule". ʻO ke kumu e hoʻohana ai nā ʻepekema haole i ka metformin ma ke ʻano he moho lāʻau kūpuna no ka mea hiki i ka metformin ke hoʻonui i ka nui o nā mole oxygen e hoʻokuʻu ʻia i nā hunaola. Ma mua o nā mea āpau, like kēia e hoʻonui ai i ke kino o ke kino a hoʻolōʻihi i ke ola.

2. Ka hoʻemi kaumaha
ʻO Metformin kahi agena hypoglycemic i hiki ke lilo i ka kaumaha. Hiki iā ia ke hoʻonui i ka ʻike insulin a hoʻoliʻiliʻi i ka synthes momona. No nā mea aloha kō he 2 ʻano nui, ʻo ka hoʻohaʻahaʻa kaumaha ʻana he mea hiki ke mālama paʻa i ke kō kō.

Ua hōʻike ʻia kahi noiʻi e ka hui noiʻi Pilikia Diabetes o ʻAmelika Hui Pū ʻIa (DPP) i loko o kahi wā noiʻi ʻole makapō o 7-8 mau makahiki, ua lilo nā mea maʻi i loaʻa i ka metformin lapaʻau i awelika o 3.1 kg ke kaupaona.

3. E hoʻemi i ka pilikia o ka hānau hānau ʻana a me ka lawe manawa ʻole no kekahi mau wahine hāpai
ʻO ka noiʻi hou loa i paʻi ʻia ma ka Lancet e hōʻike ana i ka metformin hiki ke hoʻemi i ka makaʻu o ka hānau hānau ʻole a me ka hānau mua ʻole i kekahi mau wahine hāpai.

Wahi a nā hōʻike, ua alakaʻi ka ʻepekema mai ka University of Science and Technology (NTNU) a me ka Haukapila ʻo St. Olavs i kahi noiʻi he 20 mau makahiki a ʻike ʻia ʻo nā mea maʻi me ka polycystic ovary syndrome e lawe ana i ka metformin ma ka hopena o 3 mau mahina o ka hāpai keiki e hoʻemi i ka post- hāʻule manawa a me ka hāʻule hāʻule. Pilikia o ka hānau hānau wawe.

4. Kāohi i ka mumū ma muli o ka uahi
Ua hōʻike ʻia nā hopena o ke aʻo ʻana i ke kime i alakaʻi ʻia e Professor Scott Budinger o ke Kulanui o Northwestern i hōʻoia ʻia i nāʻiole i hiki i ka metformin ke pale aku i ka hoʻowahāwahā ʻana i hana ʻia e ka smog, e pale aku i nā hunaola pale mai ka hoʻokuʻu ʻana i kahi moleola weliweli i loko o ke koko, e kāohi i ke kūkulu ʻia ʻana o ka thrombosis arterial, a no laila hoʻemi i ka ʻōnaehana cardiovascular. ʻO ka makaʻu o ka maʻi.

5. Ka palekana Cardiovascular
Loaʻa i nā Metformin nā hopena pale ʻōpū a ʻo ia wale nō ka lāʻau hypoglycemic i ʻōlelo ʻia e nā alakaʻi diabetes e like me ka hōʻike maopopo o ka pono o ka maʻi puʻuwai. Ua hōʻike ʻia nā noiʻi e pili ana ka mālama ʻana lōʻihi loa o metformin me ka hōʻemi ʻana o ka maʻi maʻi maʻi maʻi i nā maʻi diabetic ʻano 2 hou a me nā mea maʻi diabetic ʻelua i hoʻomohala mua ʻia i ka maʻi maʻi maʻi maʻi.

6. Hoʻonui i ka maʻi polycystic ovary Syndrome
ʻO ka maʻi polycystic ovary Syndrome kahi maʻi heterogeneous i hōʻike ʻia e hyperandrogenemia, hana ʻole ovarian, a me nā morphology ovary polycystic. ʻAʻole maopopo kāna pathogenesis, a he ʻokoʻa mau nā degere o ka hyperinsulinemia. Ua hōʻike ʻia nā noiʻi e hiki i ka metformin ke hōʻemi i ke kūpaʻa o ka insulin, hoʻihoʻi i kāna hana ovulation, a hoʻomaikaʻi i ka hyperandrogenemia.

7. Hoʻonui i ka flora ʻōpū
Ua hōʻike ʻia nā noiʻi e hiki i ka metformin ke hoʻihoʻi i ka mahele o ka flora ʻōpū a hoʻololi iā ia i kahi ala kūpono i ke olakino. Hāʻawi ia i kahi nohona maikaʻi loa no nā bacteria maikaʻi i loko o nā ʻōpū, a laila e hoʻohaʻahaʻa ana i ke kō a me ka hoʻoponopono pono ʻana i ka ʻōnaehana pale.

8. Manaʻo ʻia e mālama i kekahi autism
I kēia mau lā, ua ʻike nā kānaka noiʻi ma ke Kulanui ʻo McGill hiki i ka metformin ke mālama i kekahi ʻano o Fragile X Syndrome me ka autism, a ua paʻi ʻia kēia noiʻi hou i loko o ka puke pai ʻo Nature Medicine, kahi kumuwaiwai liʻiliʻi o Nature. I kēia manawa, ʻo ka autism kekahi o nā kūlana olakino a ka ʻepekema e manaʻo ai hiki ke mālama ʻia me metformin.

9. Fibrosis pulmonary hoʻohuli
Ua ʻike nā kānaka noiʻi ma ke Kulanui o Alabama ma Birmingham i ka poʻe maʻi me ka fibrosis pulmonary idiopathic a me nā hiʻohiʻona pulmonary fibrosis i hoʻokomo ʻia e bleomycin, hoʻemi ʻia ka hana o AMPK i nā mea fibrotic, a pale nā ​​mea i nā hunaola Ua hoʻonui ʻia nā myofibroblasts apoptotic.

Ke hoʻohana nei i ka metformin e hoʻoheheʻe iā AMPK ma myofibroblast hiki ke hoʻomaopopo hou i kēia mau pūnaewele i apoptosis. Eia kekahi, i ka hoʻohālikelike iole, hiki i ka metformin ke hoʻoholomua i ka hoʻopau ʻana o ka fibrotic kiko i hana ʻia. Hōʻike kēia noi e hiki ke hoʻohana i ka metformin a i ʻole nā ​​agonists AMPK e hoʻohuli i ka fibrosis i hala.

10. Kōkua i ka haʻalele ʻana i ka puhipaka
Ua ʻike nā kānaka noiʻi ma ke Kulanui o Pennsylvania e hiki i ka hoʻohana ʻana i ka nikotine wā lōʻihi ke alakaʻi i ka hoʻāla ʻana o ke ala hōʻailona AMPK, kahi i kāohi ʻia i ka wā o ka haʻalele ʻana o ka nikotine. No laila, ua hoʻoholo lākou inā hoʻohana ʻia nā lāʻau e hana i ke ala hōʻailona ʻo AMPK, hiki ke hoʻoliʻiliʻi i ka pane o ka haʻalele.

ʻO Metformin kahi agonist AMPK. I ka hāʻawi ʻana o ka poʻe noiʻi i ka metformin i nā ʻiole i haʻalele ʻia ka nikotine, ua ʻike lākou ua hoʻomaha ia i ka haʻalele ʻana o nāʻiole. Hōʻike kā lākou noiʻi e hiki ke hoʻohana i ka metformin e kōkua ai i ka haʻalele ʻana i ka puhipaka.

11. Ka hopena anti-inflammatory
I ka wā ma mua, ua hōʻike ʻia nā noiʻi preclinical a me nā clinical ʻaʻole hiki i ka metformin ke hoʻomaikaʻi wale i ka mumū mau ma o ka hoʻomaikaʻi ʻana i nā palena metabolic e like me hyperglycemia, resistence insulin a me atherosclerotic dyslipidemia, akā loaʻa pū kekahi me ka hopena anti-inflammatory pololei.

Ua kuhikuhi ʻia nā noiʻi e hiki i ka metformin ke kāohi i ka mumū, ʻo ka mea nui ma o ka kinase protein AMP-activated (AMPK) i hilinaʻi ʻia a i ʻole kūʻokoʻa kūʻokoʻa i nā mea kākau nukelea B (NFB).

12. Hoʻonā hoʻohuli hoʻohuli manaʻo
Ua hana nā kānaka noiʻi ma ke Kulanui o Texas ma Dallas i kahi laʻana o ka ʻiole e hoʻohālikelike i ka hōʻeha pili pili ʻeha i ka ʻeha. Ua hoʻohana lākou i kēia k modelkohu no ka hoʻāʻo ʻana i ka pono o nā lāʻau he nui.

Hōʻike nā hopena hoʻokolohua i ka mālama ʻana i nāʻiole me 200 mg / kg kino o ka metformin no 7 mau lā hiki ke hoʻohuli piha i ka hōʻino noʻonoʻo ma muli o ka ʻeha.

ʻO Gabapentin, kahi e mālama ai i ka neuralgia a me ka epilepsy, ʻaʻohe hopena e like me ia. ʻO kēia ka metformin hiki ke hoʻohana ʻia ma ke ʻano he lāʻau kahiko e mālama i ka hōʻino o ka naʻau i nā mea maʻi me ka neuralgia.

13. Kaohi i ka ulu ulu
I kekahi mau lā i hala aku nei, e like me ka Singularity.com, ʻike ʻia ka poʻe ʻepekema mai ka European Institute of Oncology e hiki i ka metformin a me ka hoʻokēʻai ke hana synergistically e kāohi i ka ulu ʻana o nā tumoʻiole.

Ma o ka noiʻi hou ʻana, ua ʻike ʻia ka metformin a me ka hoʻokēʻai e kāohi i ka ulu ulu ma o ke ala PP2A-GSK3β-MCL-1. Ua paʻi ʻia ka noiʻi ma Cancer Cell.

14. Hiki ke pale aku i ka hoʻohaʻahaʻa macular
ʻO Kauka Yu-Yen Chen mai ka haukapila ʻo Taichung Veterans General ma Taiwan, ua ʻike ʻo Kina i kēia manawa ʻo ka hōʻemi ʻana o ka macular degeneration (AMD) pili i nā makahiki me ka maʻi diabetes type 2 e lawe ana i ka metformin he haʻahaʻa haʻahaʻa loa ia. Hōʻike kēia ʻoiai ke kaohi nei i ka maʻi diabetes, ʻo ka anti-inflammatory a me nā hana antioxidant o metformin i kahi hopena pale ma AMD.

15. A i ʻole hiki ke mālama i ka nalo ʻana o ka lauoho
ʻO ka hui o Huang Jing, he ʻepekema Kina ma ke Kulanui o Kaleponi, Los Angeles, ua ʻike he hiki i nā lāʻau e like me metformin a me rapamycin ke hoʻoulu i nā lauoho lauoho i ka manawa hoʻomaha o nāʻiole e komo i ka wā ulu a hāpai i ka ulu ʻana o ka lauoho. Ua paʻi ʻia ka noiʻi e pili ana i ka puke pai ʻike naʻau ʻo Cell Reports.

Eia kekahi, ke hoʻohana nā ʻepekema i ka metformin e mālama ai i nā mea maʻi me ka polycystic ovary syndrome ma Kina a me India, ua ʻike pū lākou e pili ana ka metformin me ka hoʻoliʻiliʻi o ka nalo ʻana o ka lauoho.

16. Makahiki biology hoʻohuli
I kēia mau lā, ua paʻi ka pūnaewele kūhelu o ka ʻepekema ʻepekema a me ka ʻenehana ʻenekema "Nature" i kahi nūhou blockbuster. Hōʻike nā hōʻike e hōʻike ana kahi noiʻi olakino liʻiliʻi ma Kaleponi no ka manawa mua hiki ke hoʻololi i ka uaki epigenetic kanaka. I ka makahiki i hala iho nei, ua lawe ʻeiwa mau limahana olakino olakino i ka hui ʻana o ka hormone ulu a me ʻelua mau lāʻau diabetes, e like me ka metformin. Ana ʻia ma ke kālailai ʻana i nā māka ma ka genome o ke kanaka, ua iho ko lākou makahiki biology i ka awelika o 2.5 mau makahiki.

17. Hiki i nā lāʻau hoʻohui ke mālama i ka maʻi ʻaʻai ʻekolu-ʻole
I kekahi mau lā i hala aku nei, ua ʻike ʻia kahi kime e alakaʻi ʻia e Dr. Marsha rich rosner o ke Kulanui o Chicago i ka hui pū ʻana o metformin a me kekahi lāʻau ʻē aʻe, heme (panhematin), hiki ke hoʻopaʻa i ka mālama ʻana i ka maʻi ʻaʻai ʻekolu maikaʻi ʻole e hoʻoweliweli loa i ke olakino wahine. .

A aia he hōʻike e maikaʻi paha kēia hoʻolālā lapaʻau no nā ʻano maʻi like ʻole e like me ka maʻi ʻaʻa pūpū, maʻi ʻaʻai kidney, maʻi ʻaʻai uterine, maʻi ʻaʻai prostate a me ka leukemia myeloid nui. Ua paʻi ʻia ka noiʻi pili i ka puke pai ʻoi loa.

18. Hiki ke hōʻemi i nā hopena maikaʻi ʻole o nā glucocorticoids
I kēia mau lā, ua paʻi ʻo "The Lancet-Diabetes and Endocrinology" i kahi noiʻi - ua hōʻike nā hopena o ka noiʻi ma kahi pae 2 hoʻokolohua hoʻokolohua, metformin i hoʻohana ʻia i nā mea maʻi me nā maʻi kūpilikiʻi hiki ke hoʻomaikaʻi i ke olakino metabolic a hoʻēmi i ka mālama ʻana i ka glucocorticoid Nā hopena koʻikoʻi.

Ua ʻōlelo ʻia nā hoʻokolohua e hana paha ka metformin ma o ka key metabolic protein AMPK, a ʻo ke ʻano o ka hana ke kūlike ʻole o ka glucocorticoids, a he hiki ke hoʻohuli i nā hopena i hopena ʻia e ka hoʻohana nui ʻana o nā glucocorticoids.

19. Lana ka manaʻo e mālama i nā sclerosis he nui
Ma mua, ua alakaʻi ʻia kahi hui noiʻi e Robin JM Franklin o ke Kulanui o Cambridge a me kāna haumāna ʻo Peter van Wijngaarden i kahi ʻatikala ma ka puke pai kiʻekiʻe "Cell Stem Cells" ua loaʻa iā lākou kahi ʻano kūikawā o nā ʻelele neural kūpuna i hiki ke ola hou ma hope o ka lapaʻau ʻana me metformin. I ka pane ʻana i nā hōʻailona hoʻolauloa hoʻokaʻawale, hōʻike hou ia i ke ola ʻōpio a hoʻonui hou i ka hoʻoulu hou ʻana o ka myelin nerve.

ʻO kēia mea i manaʻo ʻia e hoʻohana ʻia ka metformin i ka mālama ʻana i nā maʻi e pili ana i ka neurodegeneration hiki ʻole ke hoʻololi ʻia, e like me ka sclerosis he nui.


Ka manawa o ka manawa: Apr-21-2021