Hoʻohana ʻia nā hoʻomākaukau lāʻau he nui i ka papa, granule, pauka, a me ke ʻano wai.Ma keʻano laulā, aia kahi hoʻolālā papa i ke ʻano i hōʻike ʻia i nā poʻe maʻi e ale a nau paha i kahi kiko o ka lāʻau lapaʻau.Eia naʻe, paʻakikī ka poʻe maʻi maʻi maʻi maʻi a me nā keiki maʻi i ka nau ʻana a i ʻole ka ʻai ʻana i nā ʻano lāʻau paʻa.Ua puka mai nā papa hoʻoheheʻe waha (ODT) e hoʻokō i kēia pono.Eia nō naʻe, no kekahi poʻe maʻi, ʻo ka makaʻu o ka ʻai ʻana i ke ʻano ʻano mea paʻa paʻa (papa, capsule), a me ka pilikia o ka asphyxiation e mau ana ʻoiai nā manawa pōkole.ʻO nā ʻōnaehana hoʻopuka lāʻau oral thin film (OTF) kahi koho ʻoi aku ka maikaʻi ma lalo o kēia mau kūlana.ʻAʻole lawa ka bioavailability waha o nā lāʻau he nui ma muli o nā enzymes, ka mua-pass metabolism maʻamau, a me ka pH o ka ʻōpū.ʻO ia mau lāʻau lapaʻau maʻamau ua hāʻawi ʻia ma ka makua a ua hōʻike i ka haʻahaʻa o ka mālama ʻana i ka maʻi.ʻO nā kūlana e like me kēia ua paʻa ke ala no ka ʻoihana lāʻau e hoʻomohala i nā ʻōnaehana ʻē aʻe no ka lawe ʻana i nā lāʻau lapaʻau ma o ka hoʻomohala ʻana i nā kiʻiʻoniʻoni lahilahi dispersible/dissolving i loko o ka waha.ʻO ka makaʻu i ka make ʻana, kahi pilikia me ka ODT, ua pili pū me kēia mau hui maʻi.ʻO ka hoʻoheheʻe wikiwiki a me ka hoʻokaʻawale ʻana o nā ʻōnaehana lawe lāʻau OTF he koho maikaʻi loa ia i nā ODT i nā maʻi me ka makaʻu i ka asphyxiation.Ke kau ʻia ma ke alelo, pulu koke ʻia nā OTF me ka kohu.ʻO ka hopena, ua hoʻopuehu ʻia lākou a / a i hoʻoheheʻe ʻia e hoʻokuʻu i ka lāʻau no ka systemic a / a i ʻole ka absorption kūloko.
Hiki ke wehewehe ʻia nā kiʻiʻoniʻoni hoʻoheheʻe a hoʻoheheʻe waha e like me kēia: "ʻO kēia nā ʻōnaehana lawe lāʻau e hoʻokuʻu koke lākou i ka lāʻau ma o ka hoʻoheheʻe ʻana a i ʻole ka hoʻopili ʻana i ka mucosa me ka kohu i loko o kekahi mau kekona no ka mea aia nā polymers hiki ke hoʻoheheʻe ʻia i ka wai ke kau ʻia. ma ka waha a ma ke alelo paha”.ʻO ka sublingual mucosa he kiʻekiʻe ka membrane permeability ma muli o kona ʻano membrane lahilahi a me ka vascularization kiʻekiʻe.Ma muli o kēia hāʻawi koko wikiwiki, hāʻawi ia i ka bioavailability maikaʻi loa.Hoʻonui ʻia ka bioavailability ʻōnaehana ma muli o ka lele ʻana i ka hopena mua-pass a ʻoi aku ka maikaʻi o ka permeability ma muli o ke kahe koko kiʻekiʻe a me ke kahe lymphatic.Eia kekahi, ʻo ka mucosa waha he ala maikaʻi loa a koho ʻia o ka hāʻawi ʻana i ka lāʻau lapaʻau ma muli o ka nui o ka ʻili a me ka maʻalahi o ka noi no ka absorption.6 Ma ke ʻano laulā, ʻike ʻia nā OTF ma ke ʻano he ʻāpana polymer lahilahi a maʻalahi, me ka plasticizers a i ʻole. kā lākou ʻike.Hiki ke'ōleloʻia he mea hoʻohaʻahaʻa aʻoi aku ka maikaʻi o ka poʻe maʻi, no ka mea, he lahilahi a maʻalahi i ko lākouʻano kūlohelohe.ʻO nā kiʻiʻoniʻoni lahilahi nā ʻōnaehana polymeric e hāʻawi i nā koi he nui i manaʻo ʻia no kahi ʻōnaehana lawe lāʻau.I nā haʻawina, ua hōʻike nā kiʻi ʻoniʻoni i ko lākou hiki ke hoʻomaikaʻi i ka hopena mua o ka lāʻau lapaʻau a me ka lōʻihi o kēia hopena, hoʻemi i ka pinepine o ka dosing, a me ka hoʻonui ʻana i ka pono o ka lāʻau.Me ka ʻenehana kiʻiʻoniʻoni lahilahi, hiki ke hoʻopau i nā hopena ʻaoʻao o nā lāʻau lapaʻau a hōʻemi i ka metabolism maʻamau i loaʻa e nā enzyme proteolytic.Pono nā kiʻi ʻoniʻoni lahilahi maikaʻi e loaʻa nā waiwai i makemake ʻia o kahi ʻōnaehana lawe lāʻau, e like me ka hiki ke hoʻouka lāʻau kūpono, ka hoʻopuehu wikiwiki ʻana, a i ʻole ka hoʻohana lōʻihi ʻana a me ke kūpaʻa o ka hoʻokumu ʻana.Eia kekahi, pono lākou e nontoxic, biodegradable a biocompatible.
Wahi a ka American Food and Drug Administration (FDA), ua wehewehe ʻia ʻo OTF "me hoʻokahi a ʻoi aku ka nui o nā mea lāʻau lapaʻau ikaika (API), kahi kaula maʻalahi a ʻaʻole palupalu i kau ʻia ma ke alelo ma mua o ka hele ʻana i loko o ka ʻōpū o ka ʻōpū. ʻo ka hoʻoheheʻe wikiwiki ʻana a i ʻole ka hemo ʻana i loko o ka saliva.ʻO ka OTF i kauoha mua ʻia ʻo Zuplenz (Ondansetron HCl, 4-8 mg) a ua ʻae ʻia i ka makahiki 2010. Ua hahai koke ʻo Suboxon (buprenorphine a me naloxan) e like me ka lua i ʻae ʻia.Hōʻike nā helu helu he ʻehā o ʻelima mau mea maʻi e koho i nā ʻano hoʻoheheʻe waha / disintegrating ma luna o nā ʻano mea paʻa paʻa waha. , nā ma'i ma'i, ka hānō, nā ma'i o ka'ōpū, ka 'eha, nā ho'opi'i snoring, nā pilikia moe, a me nā hui multivitamin, etc. Loa'a nā OTF a ho'omau i ka ho'onui. hoʻonui i ka pono o ka API.Eia kekahi, ʻo nā kiʻiʻoniʻoni waha ka hemo a me ka hemo ʻana me ka wai kohu liʻiliʻi ma lalo o hoʻokahi minuke i hoʻohālikelike ʻia me nā ODT.1
Pono e loaʻa i kahi OTF nā hiʻohiʻona kūpono
-Pono ka ʻono
-ʻO nā lāʻau lapaʻau e kūpaʻa loa a hiki ke hoʻoheheʻe ʻia i loko o ke kohu
- Pono ke kū'ē kū'ē kūpono
-Pono ia e hoʻokaʻawale ʻia i loko o ka pH waha waha
-E hiki ke komo i ka mucosa waha
-Pono hiki ke loaʻa ka hopena wikiwiki
ʻO nā mea maikaʻi o OTF ma mua o nā ʻano meaʻai ʻē aʻe
-Maikaʻi
-ʻAʻole pono e hoʻohana i ka wai
-Hiki ke hoʻohana palekana ʻia inā ʻaʻole hiki ke komo i ka wai (e like me ka huakaʻi)
-ʻAʻohe pilikia o ka ʻūhā
-Hoʻonui paʻa
-Maʻalahi e hoʻopili
- Hoʻohana maʻalahi i nā maʻi noʻonoʻo a pili ʻole
- He liʻiliʻi a ʻaʻohe koena i loko o ka waha ma hope o ka noi ʻana
-Kai ʻana i ka ʻōpū o ka ʻōpū a pēlā e hoʻonui ai i ka bioavailability
- Haʻahaʻa dosage a me nā hopena ʻaoʻao haʻahaʻa
- Hāʻawi ia i ka ʻoi aku ka pololei i ka wā e hoʻohālikelike ʻia i nā ʻano wai wai
-ʻAʻole pono e ana, he mea koʻikoʻi koʻikoʻi ia i nā ʻano wai wai
-E waiho ana i ka manao maikai ma ka waha
- Hāʻawi i ka hoʻomaka wikiwiki ʻana o nā hopena i nā kūlana e koi ana i ka hana wikiwiki, no ka laʻana, nā hōʻeha maʻi e like me ka hānō a me nā maʻi intraoral
- Hoʻonui i ka helu absorption a me ka nui o nā lāʻau lapaʻau
- Hāʻawi i ka bioavailability i hoʻonui ʻia no nā lāʻau liʻiliʻi liʻiliʻi i ka wai, ʻoi aku ma o ka hāʻawi ʻana i kahi ākea ākea ʻoiai e hoʻoheheʻe wikiwiki ʻia.
-ʻAʻole pale i nā hana maʻamau e like me ka ʻōlelo a me ka inu ʻana
- Hāʻawi i ka lawelawe ʻana i nā lāʻau lapaʻau me ka nui o ka pilikia o ka hoʻopilikia ʻana i ka ʻōpū o ka ʻōpū
- Loaʻa i kahi mākeke hoʻonui a me nā ʻano huahana
- Hiki ke hoʻomohala ʻia a kau ʻia ma ka mākeke i loko o 12-16 mau mahina
No ka punaewele kēia ʻatikala, e ʻoluʻolu e kelepona mai no ka hewa!
©Kuleana kope2021 Turk J Pharm Sci, Paʻi ʻia e Galenos Publishing House.
Ka manawa hoʻouna: Dec-01-2021